3 days ago · Remarkably, disabling just two previously unknown genes restored the tumor-killing power of exhausted T cells while preserving their ability to provide lasting immune protection.

During hepatitis B virus (HBV) infection, cytotoxic T cells kill infected cells and produce antiviral cytokines capable of purging HBV from viable hepatocytes. They also play an important pathogenic …

This review will focus on the role of cell death regulation in the maintenance of T-cell homeostasis as well as T cell-mediated elimination of infected or dysfunctional cells, and will summarize and discuss …

Feb 4, 2026 · By revealing how killer T cells choose between resilience and burnout, this research brings scientists closer to guiding the immune system with intention—rather than watching it fail …

Sep 1, 2021 · Here the authors show that these sublethal interactions from multiple CTL can add up over time and achieve tumour cell killing by additive cytotoxicity.

Aug 11, 2022 · Immune effector cells, including cytotoxic T cells (CTLs), induce apoptosis and eliminate target cells by direct cell–cell contacts. In vivo, CTLs fail to efficiently kill solid tumor cells by …

3 days ago · T cells fight infection through teamwork — killers destroy threats, helpers coordinate, and memory cells keep you protected long after an illness passes.

Nov 17, 2025 · T cell exhaustion is a phenomenon triggered by continued exposure to chronic infections or tumors that activate the immune system. The embattled immune cells remain capable of …

Feb 4, 2026 · This image shows killer T cells surrounding and attacking a cancer cell. A new atlas developed by researchers at UC San Diego could make it possible to design custom T cells for …

Nov 17, 2025 · The team found that cancer cells use a little-known molecular signal to push T cells into exhaustion, making them stop attacking. By interrupting this harmful signal, researchers were able to …