The colorful dots at the center are cytotoxic granules used to destroy infected or cancerous cells. Credit: F. Lemaitre @ ...

By deploying a "tag and sort" fix using E3 ligases, scientists successfully cleared the protein buildup and restored T-cell ...

Scientists want to know what causes B cells — which direct T cells to attack cancer — to malfunction and how they can be ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

T cells are crucial components of our immune system, serving as critical protectors against infection and disease. But there are limits to their defensive capabilities. T cells are not inexhaustible ...

Why structure matters: Scientists modeled how the thymus develops its convoluted shape, showing it boosts the elimination of ...

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently ...

The body’s “killer” T cells don’t just attack—they strike with astonishing precision, forming a tiny, highly organized contact zone that lets them destroy dangerous cells without harming their ...

Immunotherapy has transformed cancer care, offering a way to harness the body’s own immune system to fight tumors. But even with these advances, many patients still don’t respond. One major barrier to ...

A type of immune cell circulating in the blood contributes to cognitive ageing, and blocking its effects can reverse the ...

Chimeric antigen receptor T cell (CAR-T) therapies have revolutionized treatment for various blood cancers. When traditional treatments fail, CAR-T therapies provide a second highly effective option.