Some of the site's predictions differ from NFL Week 12 odds and other NFL Week 12 picks for NFL Week 12 games. How correct will the analytics be this week? Click on each game for more NFL Week 12 predictions for that NFL matchup. All times MST. The site allows for the possibility of ties, so the numbers add up to just less than 100%.

The Colts are coming off their bye week and the Chiefs have lost two straight. Kansas City is 0-5 in one-possession games.

The Week 12 NFL odds feature four games with a spread of a field goal or less, while three contests have a double-digit NFL line. Amongst the former are Steelers vs. Bears (-2.5), with Aaron Rodgers' (wrist) listed as questionable,

A massive NFC matchup takes place in Week 12 of the 2025 season, as the Los Angeles Rams are home favorites against the Tampa Bay Buccaneers on Sunday Night Foo

Stafford is on a historic tear, with 25 touchdowns and no interceptions since Week 3. He leads the NFL with 30 touchdown passes. The Rams have the best record in the NFC, and being the quarterback on a No. 1 seed has been the winning formula for MVP voters for many years.

The Bengals will also be without wide receiver Ja'Marr Chase, who is serving a one-game suspension, and defensive end Trey Hendrickson. Those are big losses for the 3-7 Bengals when playing host to a 9-2 Patriots team led by MVP-candidate quarterback Drake Maye.