The Carolina Panthers and the San Francisco 49ers take the field for NFL Monday Night Football tonight in Week 12. MNF start time, schedule and how to watch.

Week 12 of the 2025 NFL season concluded with a matchup that carried playoff implications for both teams as the San Francisco 49ers (8-4) defeated the Carolina Panthers (6-6) on Monday Night Football.

Christian McCaffrey was the catalyst for San Francisco, totaling 142 scrimmage yards with a rushing score, while George Kittle tacked on six catches for 78 yards.