New antibodies recognize mutant KRAS fragments displayed on tumor cells, unlocking a way to target pancreatic, colorectal, and lung cancers.

There's one type of Alzheimer's that's only ever been found in two families and two other individuals, caused by what's known as the Flemish amyloid-beta precursor protein (APP) mutation. This is a ...

In simple terms: a mutation is a stable change in genetic sequence that can be copied when cells or viruses replicate. Most mutations have no detectable effect, some contribute to disease, and a small ...

Although the genetic cause of many diseases have been identified, it’s estimated that as many as 70% of patients with a rare disorder do not know what causes their disease. Millions of people live ...

A hallmark of Parkinson's disease is the buildup of Lewy bodies—misfolded clumps of the protein known as alpha-synuclein. Long before Lewy bodies form, alpha-synuclein can interfere with neurons' ...

A research team led by Purdue University's W. Andy Tao has discovered a new type of protein modification related to cellular mutation that impairs a crucial enzyme's ability to help drive energy ...

Scientists at the Baylor College of Medicine say they have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called ...

Weill Cornell Medicine researchers have mapped how a protein tied to Parkinson's disease changes between active and inactive forms, revealing why mutations in different parts of the protein can ...

ALS-causing NEK1 gene mutations disrupt cellular protein production machinery. Truncated NEK1 protein accumulates in the nucleolus, impairing ribosome biogenesis. This disruption leads to cell death ...

Researchers from The University of Texas MD Anderson Cancer Center identified a new role for heat shock protein 90 (HSP90) in cancer predisposition and treatment resistance. Their discovery, published ...