Double-strand breaks (DSBs) can be repaired by several homologous recombination (HR)-mediated pathways, including double-strand break repair (DSBR) and synthesis-dependent strand annealing (SDSA). a | ...

DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes. DNA can be damaged by various factors such as radical metabolites, radiation, and some toxic ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break involves the severing of both strands of the DNA double ...

Divya Ramalingam Iyer, Naoya Harada, Connor Clairmont, Lige Jiang, David Martignetti, Huy Nguyen, Yizhou Joseph He, Dipanjan Chowdhury, Alan D. D’Andrea Proceedings of the National Academy of Sciences ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...

DNA-PK can help repair DNA double-stranded breaks in one of two ways. For breaks with missing information, it can target enzymes that can fill in missing nucleotides — sort of like a needle and thread ...

One of the hallmarks of DNA damage is the rapid spreading of phosphorylated histone H2A (γ-H2AX) around a DNA double-strand break (DSB). In the budding yeast Saccharomyces cerevisiae, nearly all H2A ...

You can always be judged by your scars. This is the idea that sums up what researchers at Spanish National Cancer Research Centre (CNIO) claim is one of the new breakthroughs in basic and biomedical ...

(Nanowerk News) A team of researchers from Michigan State University’s College of Veterinary Medicine has made a discovery that may have implications for therapeutic gene editing strategies, cancer ...