Millimetre-sized single crystals of covalent organic frameworks have been constructed by taking advantage of a reversible dimerization reaction of nitroso groups. Scientists and non-scientists alike ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

Chemistry students the world over are familiar with covalent bonds and hydrogen bonds. Now a study has revealed a strange variety of bond that acts like a hybrid of the two. Its properties raise ...

When most small-molecule drugs meet a protein target, they nestle close to their intended. But the flirtatious relationship between drug and target is often fleeting, with the drug repeatedly drifting ...