Cancer cells rapidly adapt to treatments, developing resistance that makes chemotherapy less effective. Researchers used an existing anti-inflammatory drug to disrupt cancer cells’ ability to adapt by ...

Aging is accompanied by widespread epigenetic reprogramming, including the loss of heterochromatin and altered chromatin-associated processes. These changes compromise transcriptional precision and ...

In a wholly new approach to cancer treatment, Northwestern University biomedical engineers have doubled the effectiveness of chemotherapy in animal experiments. Instead of attacking cancer directly, ...

This work delineates how Setd2-mediated epigenetic reprogramming overcomes developmental barriers in cloned embryos. Comparative analysis revealed that SCNT embryos exhibit excessive H3K4me3 and ...

It is still not fully understood how, despite having the same set of genes, cells turn into neurons, bones, skin, heart, or roughly 200 other kinds of cells, and then exhibit stable cellular behavior ...

Cancer researchers have long treated genetic chaos and epigenetic rewiring as separate engines of disease, two parallel hallmarks that help tumors grow, spread, and resist treatment. Now a new wave of ...